Volume-7 , Issue-2 , Apr 2020, ISSN 2455-3174 (Online) Go Back

• Open Access   Article

  Separation of a mixture of benzoic acid (C₆H₅COOH) and benzophenone (C₆H₅COC₆H₅) by extraction

  Ilias Darsaklis

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.1-3, Apr-2020

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  Extraction is a technique used to isolate and purify organic compounds when they are in a mixture with other compounds. The reactions between acids and bases were initially studied, with the solubilization and recovery of both the acidic and the basic properties of the compounds. Benzoic acid, naphthole and acetic acid are the acids that reacted with ΝaOΗ, Na2CO3 and NaHCO3 and the corresponding salt was formed. Naphtol did not react with NaHCO3 because it is a weaker acid. Depending on the ability to react with or not an acid with carbonates, the compound can be identified as carboxylic acid or phenol. Salt solutions were neutralized with HCl and the original insoluble acids were re-formed. This was followed by the dissolution of amine with HCl to form its salt, and the original molecule was recovered with NaOH. In addition, a mixture of benzoic acid and benzophenone was separated by extraction. Dichloromethane was used as the solvent and the solution was dissolved with NaOH. As a result, benzoic acid was moved to the aqueous layer as salt and benzophenone was moved to the organic layer. After these two layers were separated, the salt of the benzoic acid was neutralized with HCl and the initial acid was formed.

  Key-Words / Index Term
  Extraction, Separation, Benzoic Acid, Benzophenone, Phenol

  References
  [1]. J.C. Gilbert, S.F. Martin, Experimental Organic Chemistry, a Miniscale and Microscale Approach, Brooks/Cole Publisher, USA, pp. 153-178, 2011
  [2]. R.B. Thompson, Illustrated Guide to Home Chemistry Experiments, All Lab, No Lecture, O’Reilly Publication, USA, pp. 105-107, 2008
  [3]. R. Blumberg, Liquid-Liquid Extraction, Academic Press Publisher, USA, pp. 73-92, 1988
  [4]. L.G. Wade Jr., Organic Chemistry, Pearson Education Publication, USA, pp. 944-948, 2013
  [5]. J. McMurry, Organic Chemistry, Crete University Press Publisher, Greece, pp. 1140- 1166, 1204-1218, 2012
  

  Citation
  Ilias Darsaklis, "Separation of a mixture of benzoic acid (C₆H₅COOH) and benzophenone (C₆H₅COC₆H₅) by extraction," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.1-3, 2020

• Open Access   Article

  Effects of Dissipation on Magneto-Convection Flow over a Shrinking Surface with Chemically Reactive Species under the Influence of Radiation and Internal Heat Generation

  J. Wilfred Samuel Raj, S.P. Anjali Devi

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.4-12, Apr-2020

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  Abstract
  The effects of chemical reaction and dissipation on nonlinear MHD flow over a shrinking surface subjected to heat and mass flux under the influence of radiation and internal heat generation have been analyzed. Similarity transformations are utilized to obtain the nonlinear ordinary differential equations from nonlinear partial differential equations. Nachtsheim Swigert shooting iteration scheme together with Runge Kutta fourth order method is applied to the reduced highly nonlinear equations. Effects of pertinent parameters on heat and mass transfer characteristics are thoroughly examined. From the investigation it is noted that the species concentration boundary layer thickness reduces due to increase in Schmidt number and Chemical reaction parameter.

  Key-Words / Index Term
  Forced convection; thermal radiation; Chemical reaction; Heat and mass flux.

  References
  [1] P.L. Chambre, J.D. Young, “On diffusion of a chemically reactive species in a laminar boundary layer flow”, Physics of Fluids, Vol.1, pp.48-54, 1958.
  [2] H.I. Anderson, O.R. Hansen, B. Holmedal, “Diffusion of a chemically reactive species from a stretching sheet”, International Journal of Heat and Mass Transfer, Vol.37, Issue. 4, pp.659-664, 1994.
  [3] Afify, “MHD free convective flow and mass transfer over a stretching sheet with chemical reaction”, Heat transfer, Vol. 40, Issues. 6-7, pp.495-500, 2004.
  [4] I.U. Mbeledogu, A. Ogulu, “Chemical reaction, heat and mass transfer on MHD flow over a vertical stretching surface with heat source and thermal stratification effects”, International Journal of Heat and Mass Transfer, Vol. 48, Issues 21-22, pp. 4557-4561, 2005.
  [5] F.T. Akyildiz, H. Bellout, K. Vajravelu, “Diffusion of chemically reactive species in a porous medium over a stretching sheet”, Journal of Mathematical Analysis and Applications , Vol.320, Issue. 1, pp.322-339, 2006 .
  [6] M.A. Mansours, N.F. El-Anssary, A.M. Aly, “Effects of chemical reaction and thermal stratification on MHD free convective heat and mass transfer over a vertical stretching surface embedded in a porous media considering Soret and Dufour numbers”, Chemical Engineering Journal, Vol. 145, Issue. 2, pp. 340-345, 2008.
  [7] R.A. Mohamed, S.M. Abo-Dahab, “Influence of chemical reaction and thermal radiation on the heat and mass transfer in MHD micropolar flow over a vertical moving porous plate in a porous medium with heat generation”, International Journal of Thermal Sciences, Vol. 48, Issue. 9, pp.1800-1813, 2009.
  [8] K. Bhattacharyya, G.C. Layek, “Chemically reactive solute distribution in MHD boundary layer flow over a permeable stretching sheet distribution in MHD boundary layer flow over a permeable stretching sheet with suction or blowing”, Chemical Engineering Communications, Vol. 197 Issue. 12, pp.1527-1540, 2010.
  [9] M.h. Yazdi, S. Abdullah, I. Hashim, K. Sopian, “Slip MHD liquid flow and heat transfer over non-linear permeable stretching surface with chemical reaction”, International Journal of Heat and Mass Transfer, Vol. 54, Issues. 15-16, pp. 3214-3225, 2011.
  [10] M. Miklavcic, C.Y. Wang, “Viscous flow due to a shrinking sheet”, Quarterly of Applied Mathematics, Vol. 64, Issue. 2, pp.283-290, 2006.
  [11] T. Fang, “Boundary layer flow over a shrinking sheet with power law velocity” International Journal of Heat and Mass Transfer, Vol. 51, Issue. 25-26, pp.5838-5843, 2008.
  [12] B. Yao, J. Chen, “A new analytical solution branch for the Blasius equation with shrinking sheet”, Applied Mathematics and Computation, Vol. 215, Issue. 3, pp. 1146-1153, 2009.
  [13] N.M.F. Noor, I. Hasim, MHD flow and heat transfer adjacent to permeable shrinking sheet embedded in a porous medium, Sains Malaysian, Vol. 38, Issue. 4, pp.559-565, 2009.
  [14] S. Nadeem, Anwar Hussain, “MHD flow of a viscous fluid on a nonlinear porous shrinking sheet with homotopy analysis method”, Applied Mathematics and Mechanics, Vol. 30, Issue. 12, pp.1569-1578, 2009.
  [15] F. Ali, R. Nazar, N. Arfin, “MHD viscous flow and heat transfer due to a permeable shrinking sheet with prescribed surface heat flux”, WSEAS Transactions on Mathematics, World Scientific and Engineering Academy and Society, Vol. 9, Issue. 5, pp. 365-375, 2010.
  [16] T. Fang, J. Zhang, "Thermal boundary layers over a shrinking sheet: an analytical solution”, Acta Mechanica, Vol. 209, Issues. 3-4, pp.325-343, 2010.
  [17] T. Javed, Z. Abbas, M. Sajid, N .Ali, “Heat transfer analysis for a hydromagnetic viscous fluid over a non-liner shrinking sheet”, International Journal of Heat and Mass transfer , Vol. 54, Issues. 9-10, pp. 2034-2042, 2011.
  [18] K. Bhattacharyya, G.C. Layek, “Effects of suction/blowing on steady boundary layer stagnation-point flow and heat transfer towards a shrinking sheet with thermal radiation”, International Journal of Heat and Mass Transfer, Vol. 54, Issues. 1-3, pp. 302-307, 2011.
  [19] K. Bhattacharyya, S. Mukhopadhyay, G.C. Layek, I. Pop, “Effects of thermal radiation on micropolar fluid flow and heat transfer over a porous shrinking sheet”, International Journal of Heat and Mass Transfer , Vol. 55, Issue. 11-12, pp. 2945-2952, 2012.
  [20] T. Hayat, Z. Abbas, N. Ali, “ MHD flow and mass transfer of a upper-convected maxwell fluid past a porous shrinking sheet with chemical reaction species”, Physics letters A , Vol. 372, Issue. 26, pp. 4698-4704, 2008.
  [21] Muhaimin, R. Kandasamy, I. Hashim, “Effect of chemical reaction, heat and mass transfer on nonlinear boundary layer past a porous shrinking sheet in the presence of suction”, Nuclear Engineering and Design, Vol. 240, Issue. 5, pp. 933-939, 2010.
  [22] C. Midya, “Exact solutions of chemically reactive solute distribution in MHD boundary layer flow over a shrinking surface”, Chineese physics letter, Vol. 29, Issue. 1, pp.1-4, 2012.
  [23] S. Khalid, S. Hussain, H. Waqas, “Numerical solution of MHD flow and heat transfer in porous medium over a porous shrinking surface with radiation and viscous dissipation”, Sci.Int.(Lahore), Vol. 28, Issue. 5, pp. 4297-4302, 2016. ISSN 1013-5316.
  [24] F. Kamal, K. Zaimi, A. Ishak, I. Pop, “Stability analysis of mhd stagnation-point flow towards a permeable stretching/shrinking sheet in a nanofluid with chemical reactions effect”, Sains Malaysiana, Vol. 48, Issue. 1, pp. 243–250, 2019.
  [25] M.Q. Brewster, “Thermal radiative transfer properties”, Wiley, Canada.
  [26] A. Raptis, C. Perdikis, H. S. Takhar, “Effect of thermal radiation on MHD flow,” Applied Mathematics and Computation, Vol. 153, Issue. 3, pp. 645-649, 2004.
  

  Citation
  J. Wilfred Samuel Raj, S.P. Anjali Devi, "Effects of Dissipation on Magneto-Convection Flow over a Shrinking Surface with Chemically Reactive Species under the Influence of Radiation and Internal Heat Generation," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.4-12, 2020

• Open Access   Article

  Assessment of Anti-diabetic Activity of Cassia Siamea Lam Leaves Ethanol Extract

  B. Gawade, M. Farooqui

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.13-17, Apr-2020

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  Abstract
  The species of the genus Cassia has been reported for various pharmacological activities and their rich contents of phytochemicals use to treat health related disorders. The different parts of Cassia siamea Lam plant has been traditionally used as a medicine to treat diabetes mellitus related disorders. The assessment study aimed to investigate anti-diabetic activity of locally used medicinal plant Cassia siamea Lam leaves ethanol extract by porcine pancreatic α-amylase enzyme inhibition in vitro assay. A potent enzyme inhibitory activity was showed by the leaves of Cassia siamea Lam ethanol extract. The enzyme assay-guided leaves ethanol extract led to the inhibition activity of enzyme and has potent α-amylase inhibitor content of bioactive phytochemicals. This assessment study that describes the potency of Cassia siamea Lam medicinal plant leaves has been used an alternative medicine to treat disorders of diabetes mellitus.

  Key-Words / Index Term
  Cassia siamea Lam, diabetes mellitus, α-amylase, phytochemicals, α-amylase inhibitor.

  References
  [1] D. K. Patel, R. Kumar, D. Laloo, S. Hemalatha, “Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects”, Asian Pacific Journal of Tropical Disease, Vol.2, Issue.3, pp.239-250, 2012.
  [2] J. Lamer, “The Pharmacological Basis of Therapeutics”, 7th ed., MacMillan, New York, 1985.
  [3] “The WHO Expert Committee on Diabetes Mellitus, Technical Report Series”, World Health Organization, Geneva, 1980.
  [4] J. Beroa, M. Frederich, J. Quetin-Leclercq, “Antimalarial compounds isolated from plants used in traditional medicine”, Journal of Pharmacy and Pharmacology, Vol.61, pp.1401-1433, 2009.
  [5] M. Kamagate, C. Koffi, N. M. Kouame, A. Akoubet, N. A. R. Yao, H. M. Die-Kakou, “Ethnobotany, phytochemistry, pharmacology and toxicology profiles of Cassia siamea Lam.” The Journal of Phytopharmacology, Vol.3, Issue.1, pp.57-76, 2014.
  [6] K. Alagesan, P. K. Raghupathi, S. Sankarnarayanan, “Amylase inhibitors: Potential source of anti-diabetic drug discovery from medicinal plants”, International Journal of Pharmacy & Life Sciences, Vol.3, Issue.2, pp.1407-1412, 2012.
  [7] B. N. Gawade, S. Fatema, A. Pathan, M. Farooqui, “Review on active chemical constituents of traditional medicinal plants for treatments on diabetes mellitus”, Journal of Medicinal Chemistry and Drug Discovery, Vol.2, Issue.1, pp.643-658, 2016.
  [8] S. Sundaramoorthy, S. Gunasekaran, S. Arunachalam, M. Sathiavelu, “A Phytopharmacological Review on Cassia Species”, Journal of Pharmaceutical Sciences & Research, Vol.8, Issue.5, pp.260-264, 2016.
  [9] D. Kumar, A. Karmase, S. Jagtap, R. Shekhar, K. K. Bhutani, “Pancreatic lipase inhibitory activity of cassiamin-A, a bianthraquinone from Cassia siamea”, Natural Product Communication, Vol.8, pp.195-198, 2013.
  [10] A. Seyedan, M. A. Alshawsh, M. A. Alshagga, S. Koosha, M. Zahurin, “Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review”, Evidence-Based Complementary and Alternative Medicine, pp.1-13, 2015.
  [11] M. A. Bhutkar, S. B. Bhise, “In vitro assay of alpha amylase inhibitory activity of some indigenous plants”, International Journal of Chemical Sciences, Vol.10, Issue.1, pp.457-462, 2012.
  [12] B. N. Gawade, M. Farooqui, “In vitro alpha amylase inhibitory activity study of Zizyphus mauritiana leaves ethanol extract”, Journal of Medicinal Chemistry and Drug Discovery, Vol.3, Issue.3, pp.67-76, 2017.
  [13] H. Ali, P. J. Houghton, A. Soumyanath, “α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus”, Journal of Ethnopharmacology, Vol.107, Issue.3, pp.449-455, 2006.
  [14] P. Tiwari, B. Kumar, M. Kaur, “Phytochemical screening and extraction: A review”, Internationale Pharmaceutica Sciencia, Vol.1, Issue.1, pp.98-106, 2011.
  [15] B. Gawade, M. Farooqui, “Screening of phytochemicals and in vitro antidiabetic activity of Bauhinia racemosa Lam leaves”, Asian Journal of Pharmaceutical and Clinical Research, Vol.11, Issue.6, pp.190-193, 2018.
  [16] A. U. Wurochekke, S. J. Mahmoud, B. L. A. Muhammad, “Crude extracts of leaf and stem bark of Cassia siamea have in vitro antimicrobial activity”, Open Journal of Biochemistry, Vol.1, Issue.1, pp.43-48, 2014.
  [17] S. Kumar, V. Kumar, O. Prakash, “Antidiabetic and anti-lipemic effects of Cassia siamea leaves extract in streptozotocin induced diabetic rats”, Asian Pacific Journal of Tropical Medicine, Vol.3, Issue.11, pp.871-873, 2010.
  [18] R. K. Jangiti, G. R. Battu, L. N. Majji, M. R. Talluri, “Evaluation of antidiabetic activity of Cassia siamea leaves in alloxan induced diabetic rats”, International Journal of Phytopharmacology, Vol.4, Issue.4, pp.237-240, 2013.
  [19] S. Deepa, S. Nandhini, R. Deepika, “Molecular modelling and docking studies of anthraquinones from Cassia siamea against AGTR2 inducing type II diabetes”, International Journal Current Research and Academic Review, Vol.4, Issue.3, pp.1-116, 2016.
  [20] M. K. Gafar, A. U. Itodo, “Proximate and mineral composition of hairy indigo leaves”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol.2, Issue.1, pp.669-682, 2011.
  [21] R. N. Chopra, S. L. Nayar, I. C. Chopra, V. Asolkar, K. K. Kakkar, O. J. Chakre, et al. “Second supplement to Glossary of Indian medicinal plants with active principles. Glossary Indian med Plants”, Council of Scientific & Industrial Research, New Delhi, pp.55, 1956.
  [22] R. V. Krishna Rao, M. N. Reddy, “Phyto chemical studies of cassia siamea leaves”, Cure science, Vol.47, pp.621-622, 1978.
  [23] H. Wagner, S. M. El-Sayyad, O. Seligmann, V. Mohan Chari, “Chemical Constituents of Cassia siamea Lam., I2-Methyl-5-acetonyl-7-hydroxychrornone (Cassiachromone)”, Planta Medica, Vol.33, Issue.3, pp.258-261, 1978.
  [24] B. M. Kshetra, H. Mallik, “Cassiadinine, a chromone alkaloid and (+)-6-hydroxy-mellein, a dihydroisocoumarin from Cassia siamea”, Journal of Natural Products, Vol.257, pp.1727-1730, 1986.
  [25] H. Morita, S. Oshimi, Y. Hirasawa, K. Koyama, T. Honda, W. Ekasari, G. Indrayanto, N. C. Zaini, “Cassiarins A and B, novel antiplasmodial alkaloids from Cassia siamea”, Organic Letters, Vol.9, Issue.18, pp.3691-3693, 2007.
  [26] S. Oshimi, Y. Tomizawa, Y. Hirasawa, T. Honda, W. Ekasari, A. Widyawaruyanti, M. Rudyanto, G. Indrayanto, N. C. Zaini, H. Morita, “Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A”, Bioorganic & Medicinal Chemistry Letters, Vol.18, Issue.13, pp.3761-3763, 2008.
  [27] U. Veerachari, A. K. Bopaiah, “Preliminary phyto-chemical evaluation of the leaf extract of five Cassia species”, Journal of Chemical and Pharmaceutical Research, Vol.3, Issue.5, pp.574-583, 2011.
  [28] D. M. Nyaga, P. K. Kamweru, “Phytochemical Screening of Leaves, Bark and Stem of Cassia siamea by FTIR Spectroscopy”, International Journal of Science and Research, Vol.6, Issue.9, pp.1264-1268, 2017.
  [29] J. P. Mehta, P. H. Parmar, S. H. Vadia, “Separation of Phytochemicals from leaf of Cassia siamea and their antimicrobial assay”, The Journal of Phytochemistry, Photon, pp.290-302, 2014.
  [30] L. N. Majji, G. R. Battu, R. K. Jangiti, M. R. Talluri, “Evaluation of In-Vitro Antibacterial Activity of Cassia siamea leaves”, International Journal of Pharmacy and Pharmaceutical Sciences, Vol.5, Issue.3, pp.263-265, 2013.
  [31] J. P. Mehta, P. H. Parmar, N. B. Kukadiya, D. R. Godhani, “Antimicrobial Assay of Extracts of Cassia siamea (Lam.) and Cassia javanica (Linn.)”, Journal of Pharmaceutical, Chemical and Biological Sciences, Vol.5, Issue.4, pp.386-395, 2018.
  

  Citation
  B. Gawade, M. Farooqui, "Assessment of Anti-diabetic Activity of Cassia Siamea Lam Leaves Ethanol Extract," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.13-17, 2020

• Open Access   Article

  Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Bases of 1-Amino-7-hydroxy-2-methylquinoline-4(1H)-one

  S.K. Vishwakarma, A. Pradhan

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.18-22, Apr-2020

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  Abstract
  We have synthesized eight Schiff bases of 1-amino-7-hydroxy-2-methylquinolin-4(1H)-one named as Q4AA-Q4AH by refluxing (Q4A) with substituted aromatic aldehydes in ethanol for 5-7 hrs. The final test compounds has purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline Cl 725. They have evaluated for antibacterial activity. Compounds were active against Klebsiella pneumonia and Enterococcus faecalis. Test compounds, such as Q4AD, Q4AE and Q4AF showed moderate activity against gram positive micro-organism while Q4AG and Q4AF showed activity against gram negatives organism lower than standard ciprofloxacin. Their antimicrobial activity was evaluated by wells diffusion method.

  Key-Words / Index Term
  Resacetophenone, 4-quinolone, acylchloride, pyridine, Schiff’s bases, well diffusion

  References
  [1] A. Foroumadi, Ghodsi Sh, S. Emami, S. Najjari, “Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety,’’ Bioorg. Med. Chem. Lett., 16:3499–3503, 2006.
  [2] ChG Noble, FM . Barnard, A. Maxwell, “Quinolone- DNA Interaction: Sequence-Dependent Binding to
  Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex,’’ Antimicrob. Agents Chemother, 47, 854–862, 2003.
  [3] S. Verma, A. K. Sirbaiya and S. N. Pandeya, “Antimicrobial activity of Schiff base of ciprofloxacin,” Der Pharmacia Sinica, 4(1): 1-9, 2013.
  [4] D.T.W. Chu and P.B. Fernandes,” Recent development in the field of quinolone antibacterial agent,” in advances in Drug Research, Testa B(ed.) , London, Academic Press, vol. 21,pp. 39-144 ,1991.
  [5] R. K. Shandil, R. Jayaram, P. Kaur, “Moxiflocin, Ofloxicin, Sparfloxacin and Ciprofloxacin against Mycobacterium tuberculosis:Evaluation of in Vitro and Pharmacodynamic Indices that best predict in Vivo Efficienc,” Antimicroial. Agents Chemotherapy, vol. 51, Issue 2, 576-582, 2007.
  [6] Dohrten, Diedrich, U. S. Pat, 1, 1932, 862, 361.
  [7] Tirasek et. al.,Cersk. Dermatol, 38, 1966, 41.
  [8] CT Supuran, A Casini and A Scozzafava, “Protease inhibitors of the sulphonamide type:Anticancer, anti-inflammatory and antiviral agent,” Med. Res. Rev. vol.23, Issue 5 , 535-558, 2003.
  [9] N.K. Mak, TW Kok, RN Wong, SW Lam, “Photodynamic activities of sulfonamide derivatives of pophycene on nasopharyngeal carcinoma cells,” J. Biomed. Sci., 10: 418-429, 2003.
  [10] PGD Benedetti: Advances in drug research. Testa B. Academic Press. London and New York, Vol. 16, 227-279, 1987.
  [11] T. Hokelek, H. Necefoglu, “Crystal structure of [triaqua(salicylato)(nicotinamide)zinc(II)] salicylate,” .Analytical Sciences, vol. 17, 1241–1242, 2001.
  [12] W. Baker, “Molecular rearrangement of some o-acycloxycetophenone and the mechanism of the production of 3-acylchromone,” J. Chem. Soc., 1381-1389, 1933.
  [13] R.H., Erickson, Jr. Natalie., k.J. Bock, “(aminolkoxy)chromones. Selective sigma receptor ligand,” J. Med. Chem. 35, 1526-1535, 1992.
  [14] Nuss baumer, P.,Lehr , A.J. Billich, “2-Substituted 4-(thio)Chromenone 6-o-sulfamates: potent inhibitors of human steroids sulfatase,” Med. Chem. 45, 4310-4320, 2002.
  [15] Billich,A.,Nussbaumer ,P., Schreiner,E., Schuster,I.,1999.preparation of Chromanone and Thiochromanone Derivatives as Steroid Sulfatase Inhibitors. Patent WO 9952890.
  [16] R. I. H. Al-Bayati and M. F. Radi, “Synthesis of novel 2-quinolone derivatives,”African Journal of Pure and Applied Chemistry, vol. 4, Issue 10, 228-232, 2010.
  [17] Saied M E Khalil, “Metal complex of Schiff base ligands derived from 4-hydroxy -2(1H) quinolone and ethylnediamine or 1, 2-propylenediamine,” Indian journal of chemistry 33A (9), 830-836, 1994.
  [18] S.Magaldi, “Well diffusion for antifungal susceptibility testing,” International journal of infectious diseases, 8, 39-45, 2004.
  [19] A. Sen, A. Batra, “evaluation of antimicrobial activity of different solvent extracts of medicinal plant:Melia Azedarach L,” International journal of current pharmaceutical research, Vol. 4 Issue 2, 67-73, 2012.
  [20] H. jahagirian,Md. J. haron, L. afsah-hejari, “well diffusion method for evaluation of antibacterial activity of copper phenyl fatty hydroxamate synthesided from canola and palm kernel oil,” Digest Journal of Nanomaterial and Biostructure,: Vol. 8 Issue 3, 1263-127, 2013.
  [21] Systematic organic chemistry, by W.M. Cumming, 91, 1937.
  

  Citation
  S.K. Vishwakarma, A. Pradhan, "Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Bases of 1-Amino-7-hydroxy-2-methylquinoline-4(1H)-one," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.18-22, 2020

• Open Access   Article

  Ionic liquid i.e. 1-Pentyl-3-methylimidazolium Bromide Mediated Synthesis of 2-phenylbenzoxazole

  Pawan P. Kalbende

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.23-28, Apr-2020

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  Abstract
  An efficient and green synthesis of 2-phenylbenzoxazole have been carried out by a simple condensation of 2-aminophenol and aromatic aldehyde in an inexpensive ionic liquid i.e. 1-pentyl-3-methylimidazolium bromide ([pmIm]Br) by microwave irradiation under solvent free condition. Initially, imidazolium based ionic liquid i.e. 1-Pentyl-3-methylimidazolium bromide [pmIm]Br have been synthesized by microwave irradiation from 1-methylimidazole and n-pentyl bromide. The structure of newly synthesized ionic liquid and 2-phenylbenzoxazole have been confirmed by spectral studies such as UV-Vis, FT-IR and 1H-NMR spectroscopy techniques. Ionic liquid i. e. [pmIm]Br as a reaction media offers several advantages including non-toxic, non-corrosive, shorter reaction time, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures.

  Key-Words / Index Term
  Ionic liquid, Microwave, [pmIm]Br, Imidazolium, Catalyst-free, Green chemistry

  References
  [1]. A. Rajendran, A. Selvam, C. Karthikeyan, S. Ramu, “An ionic liquid catalysed facile green synthesis of phenyl polyhydro-1, 8-acridine diones”. Int J Cur Tr Res. Vol. 1, issue 1, pp. 24-30, 2012
  [2]. J. Huddlesto, A. Viser, W. Reichert, H. Willauer, G. Broker and R. Rogers, “Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation” . Green Chem., Vol. 3, pp. 156, 2001
  [3]. Li Ruxiong, Green Solvents: Synthesis and Application of Ionic Liquids, Beijing: Chemical Industry Press, Vol. 6, 2004.
  [4]. K. Mikami, Green Reaction Media in Organic Synthesis, Blackwell Publishing, Oxford, 2005.
  [5]. A. Zare, A. Parhami, A. R. Moosavi-Zare, A. Hasaninejad, A. Khalafi-Nezhad, M. H. Beyzavi, “A catalyst-free protocol for the green and efficient condensation of indoles with aldehydes in ionic liquids”. Can. J. Chem. Vol. 87, Issue 2, pp. 416-421, 2009.
  [6]. A. Zare, A. Hasaninejad, M. H. Beyzavi, A. R. Moosavi Zare, A. Khalafi-Nezhad, F. Asadi, L. Baramaki, S. Jomhori-Angali, R. Ghaleh-Golabi, “KF/Al2O3 as a highly efficient, green, heterogeneous, and reusable catalytic system for the solvent-free synthesis of carboacyclic nucleosides via Michael addition reaction.” Synth. Commun. , Vol. 39, pp. 139 – 157, 2009.
  [7]. P. Wasserscheid, T. Welton, Ionic Liquids in Synthesis, Wiley-VCH, Weinheim, 2003.
  [8]. X. Li, W. Eli, G. Li, “Solvent-free synthesis of benzoic esters and benzyl esters in novel Brønsted acidic ionic liquids under microwave irradiation”. Catal. Commun. Vol. 9, pp. 2264-2268, 2008.
  [9]. Y. Peng, G. Song, “Microwave-assisted clean synthesis of 6-aryl-2,4-diamino-1,3,5-triazines in [Bmim][PF6]”. Tetrahedron Lett., Vol. 45, pp. 5313-5316, 2004.
  [10]. A. Romero, A. Santos, J. Tojo, A. Rodriguez, “Toxicity and biodegradability of imidazolium ionic liquids”. J Hazard Mater. Vol. 151, pp. 268–273, 2008.
  [11]. C. Benedi, F. Bravo, P. Uriz, E. Fernandez, C. Claver, and S. Castillon, “Synthesis of 2-substituted-benzothiazoles by palladium-catalyzed intramolecular cyclization of o-bromophenylthioureas and o-bromophenylthioamides”, Tetrahedron Lett., Vol. 44, pp. 6073, 2003.
  [12]. K.S.A. Vallin, P. Emilsson, M. Larhed, A. Hallberg, “High-speed Heck reactions in ionic liquid with controlled microwave heating”. J. Org. Chem., Vol. 67, pp. 6243-6246, 2002.
  [13]. J.S. Yadav, B.V.S. Reddy, L. Chetia, G. Srinivasulu, A.C. Kunwar, “Ionic liquid accelerated intramolecular hetero-Diels–Alder reactions: a protocol for the synthesis of octahydroacridines.” Tetrahedron Lett., Vol. 46, pp. 1039-1044, 2005.
  [14]. V. Namboordiri and R. S. Varma, “Solvent-Free Sonochemical Preparation of Ionic Liquids”. Org. Lett., vol. 4, issue 18, pp. 3161-3163, 2002.
  [15]. V. I. Parvulescu, C. Hardacre, “Catalysis in ionic liquids”. Chem. Rev. vol. 107, issue 6, pp. 2615–2665, 2007
  [16]. P. L. Anto, C. Y. Panicker, H. T. Varghese, D. Philip, O. Temiz-Arpaci, B. Tekiner-Gulbas, I. Yildiz, “Vibrational spectroscopic studies and ab initio calculations of 5-methyl-2-(p-fluorophenyl)benzoxazole”. Spectrochim. Acta Part A, vol. 67, pp. 744-749, 2007
  [17]. R. M. Silverstein, F. X. Webster, Spectrometric Identification of Organic Compounds, sixth ed., John Wiley, Asia, 2003.
  [18]. R. Saxena, L. D. Kaudpal, G. N. Mathur, “Synthesis and characterization of poly(benzobisthiazole)s derived from halogenated phthalic acid and isophthalic acid”. J. Polym. Sci. Part A: Polym. Chem. vol. 40, pp. 3959-3966, 2002.
  [19]. K. Nakamoto, Infrared and Raman Spectrum of Inorganic and coordination Compounds,5th ed., John Wiley and Sons, Inc., New York, 1997.
  [20]. S. Kantevari, S.V.N. Vuppalapati, L. Nagarapu, “Montmorillonite K10 catalyzed efficient synthesis of amidoalkyl naphthols under solvent free conditions”. Catal. Commun., Vol. 8, pp. 1857-1862, 2007.
  [21]. N. B. Colthup, L. H. Daly, S. E. Wiberly, Introduction to Infrared and Raman Spectroscopy, 3rd ed., Academic Press, Boston, 1990.
  [22]. J. Coates, R. A. Meyers (Ed.), Encyclopedia of Analytical Chemistry; Interpretation of Infrared Spectra, A Practical Approach, John Wiley and Sons Ltd., Chichester, 2000.
  [23]. J.S. Yadav, B.V.S. Reddy, L. Chetia, G. Srinivasulu, A.C. Kunwar, “Ionic liquid accelerated intramolecular hetero-Diels–Alder reactions: a protocol for the synthesis of octahydroacridines”. Tetrahedron Lett., Vol. 46 pp. 1039-1044, 2005.
  [24]. B.C. Ranu, S.S. Dey, A. Hajra, “Catalysis by an ionic liquid: efficient conjugate addition of thiols to electron deficient alkenes catalyzed by molten tetrabutylammonium bromide under solvent-free conditions”. Tetrahedron, Vol. 59, issue 14, 2417-2421, 2003.
  [25]. B. C. Ranu, A. Hajra, and S. S. Dey, “A practical and green approach towards synthesis of dihydropyrimidinones without any solvent or catalyst”. Org. Process Res. Dev., vol. 6, pp. 817, 2002.
  

  Citation
  Pawan P. Kalbende, "Ionic liquid i.e. 1-Pentyl-3-methylimidazolium Bromide Mediated Synthesis of 2-phenylbenzoxazole," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.23-28, 2020

• Open Access   Article

  Synthesis, Characterization and Biological Aspects of O- and N-Donor Schiff Base Ligands and their Co(ll),Cu(ll),and Ni(ll) Complexes

  Huma Chaudhry

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.29-33, Apr-2020

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  Abstract
  A Schiff base is a compound with the general structure R₂C=NR`. Schiff bases and their complexes are flexible compounds synthesized from the condensation of an amino compound with carbonyl compounds and extensively used for industrial purposes and also show a broad range of biological activities including antibacterial, antifungal, antiviral, antimalarial, antiproliferative, anti-inflammatory, anticancer, anti-HIV, anthelminthic and antipyretic properties. Many Schiff base complexes show excellent catalytic activity in various reactions and in the presence of moisture. They can be considered a sub-class of imines. The term is often synonymous with azomethine which refers specifically to secondary aldimines.These are formed by the condensation reaction of primary ammines and carbonyl compounds. Furfuraldehyde and it’s various derivatives are also useful in the synthesis of Schiff bases. Schiff base forms a stable complex with metals in +2 oxidation state. Keeping all these facts into consideration, Here four new Complexes Co(ll),Zn(ll),Ni(ll) and Cu(ll) with O- and N- donor Schiff bases derived from Furfuraldehyde and Ethylenediamine have been synthesized and Characterized. In this chemical synthesis the ligands of schiff base was synthesized by the reaction of furfuraldehyde with Ethylenediammine in 2:1 ratio respectively in methanol. The analytical results and molecular weights of the compounds support the formulations. The obtained coloured crystalline Complexes are soluble in acetone and DMF but sparingly soluble in DMSO.

  Key-Words / Index Term
  Azomethine; Biological activities; Condensation;DMF;DMSO; Furfuraldehyde; Synonymous

  References
  [1] S. Yamda, Coord. Chem. Rew., 192, 537 (1999).
  [2] G. Jian and X. Tong-Tao, Synth. React. Inorg. Met-Org Nano-Met. Chem., 38, 50 (2008).
  [3]. W. G. Hanna and M. Moawaad, Trans. Met. Chem., 26(6), 644 (2001).
  [4] Bhakti, J. Sci. Ind. Res., 114, 1213 (1953).
  [5] Z. Poddar, Ana. Chem., 154, 324 (1957).
  [6] Ullman’s Encyclopedia of Ind. Chem., Willey Veh., 26, 614 (1984).
  [7] C. H. Collins and Lye, Microbiological Methods, 4th Ed., Butterworth, London, (1976) p. 235.
  [8] A. I. Vogel, A Text Book of Quantitative Inorganic Analysis, 3rd Edn., ELBS, London (1978).
  [9] S. I. Mostafa, T. H. Rakha and M. M. El Agex, Indian J. Chem., 39(A), 1301 (2000).
  [10] R. K. Dubey, A. N. Mishra and C. H. Mishra, Proc. Nat. Acad. Sci., India, 75(A), 239 (2005).
  [11] A. P. Mishra and S. K. Gautam, J. Indian Chem. Soc., 81, 324 (2004).
  [12] M. Thomas, M. K. M. Niar and P. K. Radhakrishnan, Synth. React. Inorg. Met-Org Chem., 25, 471 (1995).
  [13] C. R. Bhattachajee, P. Goswami, S. Neogi and S. Dhibar, Assam Univ. J. Sci. and Tech.; Phy. Sci.and Tech., 5(II), 81 (2010).
  [14] W. Kemp, Organic Spectroscopy, ELBS, Hong Kong, (1987).
  [15] G. C. Percy and D. A. Throton, J. Inorg. Nucl. Chem., 34, 3357 (1972).
  [16] J. T. Makode and A. S. Aswar, Indian J. Chem., 43(A), 2120 (2004).
  [17] P. Muthumanim, S. Venkataraman, R. Meera, G. Nayak, N. Chidambaranathan, P. Devi and B. Kameshwari, Der. Pharma Chemica., 2(1), 385 (2010).
  [18] N. Raman, A. Kulandaisamy and K. Jayasubramaniam, Indian J. Chem., 41(A), 942 (2002).

  Citation
  Huma Chaudhry , "Synthesis, Characterization and Biological Aspects of O- and N-Donor Schiff Base Ligands and their Co(ll),Cu(ll),and Ni(ll) Complexes," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.29-33, 2020

• Open Access   Article

  Phytochemical screening, Anticancer and cytotoxicity of Pulicaria crispa (whole plant)

  Y. H. Elshiekh, M. A. Mageed

  Research Paper | Journal-Paper (IJSRCS)

  Vol.7 , Issue.2 , pp.34-37, Apr-2020

  Abstract

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  Abstract
  Pulicaria crispa (Asteraceae) is an indigenous plant in Western Sudan. All parts of the plant are traditionally used to heal various diseases, especially those related to the respiratory system. The aim of this study was the chemical screening of metabolites extracted from the plant. Besides, test their toxicity, and their inhibition effect on cancer cells. The metabolites were completely extracted from the plant using three methods: Soxhlet with petroleum ether, ethyl acetate, and ethanol. Maceration with 70% methanol, and decoction with distilled water. The results of chemical screening of all extracts obtained, except the petroleum ether extract, showed the presence of alkaloids, flavonoids, phenols, carbohydrates, terpenes, proteins, and lipids. The Soxhlet petroleum ether extract showed no alkaloids, carbohydrates, and proteins. The cytotoxicity of plant metabolites was tested using brine shrimp lethality assay. The results showed that Soxhlet extracts revealed significant toxicity (P <0.05) to brine shrimp larvae compared to other extracts. Anticancer was investigated by sulforodamine B (SRB) screening against three lines of cancer cells: breast cancer cell line (MCF7), colon cancer cell line (PC3), and prostate cancer cell line (HCT116). The results reflected that Soxhlet extracts had a significant effect on inhibiting the growth of breast and colon cancer cells besides ethyl acetate extract was also inhibit the growth of prostate cancer cells. The maceration and decoction extracts were revealed no anticancer activity against all cancer cells tested.

  Key-Words / Index Term
  Pulicaria crispa, Asteraceae, Cytotoxicity, Sulphorhodamine-B, Breast cancer cell, Colon cancer cell, Prostate cancer cell, Brine Shrimps.

  References
  [1] D.J.Newman, G.M. Cragg. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod; 79(3): pp.629-661, 2016.
  [2] D.L. Moreira, S.S.Teixeira, M.H.Monteiro, De-Oliveira ACAX, F.J.Paumgartten. Traditional use and safety of herbal medicines. Rev Bras Farmacogn ; 24(2): pp.248-257, 2014.
  [3] A.G. Atanasov, B. Waltenberger, E.M. Pferschy-Wenzig, T. Linder, C.Wawrosch, P.Uhrin, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv; 33(8): 1582-1614,2015.
  [4] A. Zardi-bergaoui et al., “Chemical composition and bioactivities of essential oils from Pulicaria vulgaris subsp. dentata ( Sm.) Batt. growing in Tunisia,” J. Essent. Oil Res., vol. 00, no. 00, pp. 1–10, 2019.
  [5] A. Fahmi, N. Hassanen, M. Abdur-Rahman, and E. Shams-Eldin, “Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats,” Biomarkers, vol. 24, no. 5, pp. 436–447, 2019.
  [6] Y. H. Elshiekh and M. A. M. Abdelmageed, "Antioxidant, Cytotoxicity and Antitumor of Bergia suffruticosa ( whole plant ), J. IJSRBS” vol. 6, no. 6, pp. 52–55, 2019.
  [7] A. Esmael et al., “Antimicrobial activity of certain natural-based plant oils against the antibiotic-resistant Acne bacteria,” Saudi J. Biol. Sci., 2019.
  [8] S. Pharmacological, A. Of, A. Extracts, and O. F. Some, “International Journal of Innovative Pharmaceutical Sciences and Research,” vol. 3, no. 124, pp. 124–132, 2015.
  [9] E. H. M. Ahmed, B. Y. M. Nour, Y. G. Mohammed, and H. s. Khalid, “Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine,” Environ. Health Insights, vol. 4, no. 1, 2010.
  [10] E. D. Benjamin, G. A. Ishaku, F. A. Peingurta, and A. S. Afolabi, “Callus Culture for the Production of Therapeutic Compounds,” vol. 4, no. 4, pp. 76–84, 2019.
  [11] M. Elshafei, E. Habiballa, and M. A. Mohamed, “Antibacterial Effects of Quercus Infectoria on Bacteria Isolated from Urinary Tract Infection Patients,” vol. 4, no. 3, 2019.
  [12] M. A. Mohamed, “EFFECT OF PROCESSING ON AMINO ACIDS CONTENTS OF FOUR SPECIES OF THE,” vol. 6, no. 9, pp. 3775–3780, 2015.
  [13] BIOASSAY TECHNIQUES FOR DRUG.
  [14] M. A. Emam, H. I. Khattab, and M. G. A. Hegazy, “Assessment of anticancer activity of Pulicaria undulata on hepatocellular carcinoma HepG2 cell line,” Tumor Biol., vol. 41, no. 10, pp. 1–10, 2019.
  [15] E. E. Elgorashi and L. J. Mcgaw, “South African Journal of Botany African plants with in vitro anti-in fl ammatory activities : A review,” South African J. Bot., vol. 126, pp. 142–169, 2019.
  [16] A. Activity, A. Of, and E. Extract, “International Journal of Innovative Pharmaceutical Sciences and Research ANTIBACTERIAL ACTIVITY ASSESSMENT OF RHIZOME,” vol. 5, no. 1, pp. 1–11, 2017.
  [17] S. S. Shiva, ur da clo edia. .
  [18] P. Application and D. D. From, “Biological Assay,” pp. 1–14.
  [19] B. Berke, A. Umar, C. Cheze, H. Gin, and N. Moore, “A review of Algerian medicinal plants used in the treatment of diabetes,” J. Ethnopharmacol., vol. 238, no. April, p. 111841, 2019.
  [20] O. A. O. Adam, R. S. M. Abadi, and S. M. H. Ayoub, “Effect of Extraction method and Solvents on yield and Antioxidant Activity of Certain Sudanese Medicinal Plant Extracts,” J. Phytopharm., vol. 8, no. 5, pp. 248–252, 2019.
  [21] “Phytochemical screening and Antimicrobial activity of seeds and fruits extract of Momordica balsamina Linn,” vol. 20, no. 2, pp. 1–7, 2019.
  [22] H. S. Eldeenizzeldeenabdalaziz and M. A. M. Mageed, “Photochemical Analysis, Antioxidant Activity and Cytotoxicity of Adansonia digitata L. Seeds Ethanol Extract,” vol. 1, no. 1, 2019.
  
  

  Citation
  Y. H. Elshiekh, M. A. Mageed, "Phytochemical screening, Anticancer and cytotoxicity of Pulicaria crispa (whole plant)," International Journal of Scientific Research in Chemical Sciences, Vol.7, Issue.2, pp.34-37, 2020