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Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic

R. Mishra1 , V.K. Shrivastava2

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.6 , pp.150-156, Dec-2018


CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i6.150156


Online published on Jan 01, 2018


Copyright © R. Mishra , V.K. Shrivastava . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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IEEE Style Citation: R. Mishra , V.K. Shrivastava, “Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic,” International Journal of Scientific Research in Biological Sciences, Vol.5, Issue.6, pp.150-156, 2018.

MLA Style Citation: R. Mishra , V.K. Shrivastava "Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic." International Journal of Scientific Research in Biological Sciences 5.6 (2018): 150-156.

APA Style Citation: R. Mishra , V.K. Shrivastava, (2018). Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic. International Journal of Scientific Research in Biological Sciences, 5(6), 150-156.

BibTex Style Citation:
@article{Mishra_2018,
author = {R. Mishra , V.K. Shrivastava},
title = {Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic},
journal = {International Journal of Scientific Research in Biological Sciences},
issue_date = {12 2018},
volume = {5},
Issue = {6},
month = {12},
year = {2018},
issn = {2347-2693},
pages = {150-156},
url = {https://www.isroset.org/journal/IJSRBS/full_paper_view.php?paper_id=958},
doi = {https://doi.org/10.26438/ijcse/v5i6.150156}
publisher = {IJCSE, Indore, INDIA},
}

RIS Style Citation:
TY - JOUR
DO = {https://doi.org/10.26438/ijcse/v5i6.150156}
UR - https://www.isroset.org/journal/IJSRBS/full_paper_view.php?paper_id=958
TI - Gentamicin Induced Hepatotoxicity: An approach of Hepatoprotecion by Garlic
T2 - International Journal of Scientific Research in Biological Sciences
AU - R. Mishra , V.K. Shrivastava
PY - 2018
DA - 2019/01/01
PB - IJCSE, Indore, INDIA
SP - 150-156
IS - 6
VL - 5
SN - 2347-2693
ER -

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Abstract :
Gentamicin hepatotoxicity is a major clinical drawback. This investigation was performed to scrutinize the effect of garlic extract as a herbal antidote on liver toxicity after treatment with gentamicin in male albino rats. Gentamicin is a widely used anti-infective broad-spectrum antibiotic of aminoglycoside family. Side effects of gentamicin medication occur due to free radical formation. Garlic, the bulb of Allium sativum, is universally used as a spice and also known for its medicinal and antioxidant properties. Forty adult male albino rats, Rattus norvegicus were randomly classified into four groups of ten each. Group 1 received 0.9% normal saline orally per day and served as control while group 2 received gentamicin intramuscularly per day, however group 3 received both gentamicin intramuscularly per day and garlic extract orally per day, while group 4 received only garlic extract orally per day for 30 and 60 days respectively. Gentamicin caused various structural and functional changes in hepatic cell, increased glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), acid phosphatase (ACP), alkaline phosphatase (ALP) and decreased total protein and creatinine level. Co-administration of garlic extract to rats ameliorates the gentamicin toxicity at some extent in hepatic cells as shown in the results of biochemical, enzymological and histopathological studies. Garlic extract was effective in recovering the level of hepatic enzymes, biochemical markers and histological alterations; hence, it may be concluded that garlic reduces the gentamicin hepatotoxicity in rats.

Key-Words / Index Term :
Gentamicin; Hepatotoxicity; Garlic extract; Hepatoprotection; Male Rattus norvegicus

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