Tosyl ester(s) of α-hydroxy acid(s) – Synthesis and antimicrobial studies

R. Kavitha¹ , S. Ananthalakshmi²

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.4 , pp.61-65, Aug-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i4.6165

Online published on Aug 31, 2018

Copyright © R. Kavitha , S. Ananthalakshmi . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Tosyl ester(s) of α-hydroxy acid(s) were prepared by treating the acid with p-toluenesulfonyl chloride (TsCl) in the presence of pyridine. The products were isolated, identified by TLC and characterized by IR, 1H-NMR and 13C-NMR spectral techniques. Anti microbial activity of the synthesized compounds were studied by Agar well diffusion method against two bacterial (Escherichia Coli and Staphylococus Aureus) and two fungal (Candida albicans and Aspergillus Niger) species using Ciprofloxacin against the bacterial strains, Nystatin against Candida albicans and Amphotericin against Aspergillus niger as standard antibiotics. The results infer that the tosyl ester(s) of α- hydroxy acid(s) are potentially active against bacterial and fungal strains.

Key-Words / Index Term :
Tosyl esters, α-hydroxy acids, Sulfonyl sulfur, TLC technique, Antimicrobial activity, Agar well diffusion method

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