Prognostic Role of Preoperative Circulatory Immune Cells and ratio of Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Lymphocyte-to-Monocyte in Women with Breast Cancer of Saurastra, Gujarat Re

Priya Mehta¹ , Girish K Goswami² , Nimesh Rupala³

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.4 , pp.1-7, Aug-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i4.17

Online published on Aug 31, 2018

Copyright © Priya Mehta, Girish K Goswami, Nimesh Rupala . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Cancer is one of the frequently talked and most feared diseases that have evolved, rather rapidly in the past two decades. Breast cancer, a multifactorial disease is the second most common malignancy related mortality among women worldwide. Routine diagnosis for breast cancer is usually done by mammography and histopathology, but current research data suggest that other non-disease specific biomarkers such as protein profiling, tumor specific hormones, hematocrit, serum proteins etc are also hypothesized to be associated with overall health outcome of the patients and can serve as a supplementary parameter to predict overall prognosis of the patients. The present study concerns about relative analysis of Hematocrit and WBC parameters among patients at the time of diagnosis along with the examination of ratio of Neutrophil-to-Lymphocyte (NLR), Platelet-to-Lymphocyte (PLR) and Lymphocyte-to-Monocyte (LMR) by fully automated clinical biochemistry analyzer and its correlation with other socio-demographic factors prevalent among the patients. For this purpose, preoperative blood samples of breast cancer patients were collected from Rajkot Cancer Hospital and results were compared with age and sex matched healthy volunteers. The present study conclude that high NLR ratio in 27%, high PLR ratio in 7.81 % and low LMR ratio in 14.75% of patients was obtained among the studied population.

Key-Words / Index Term :
Breast Cancer, Socio-demographic, WBC, NLR, PLR, LMR, prognosis

References :
[1]. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Donald Maxwell Parkin, David Forman and Freddie Bray. “ Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 ”. International Journal of Cancer, Volume 136 Issue 5 : E359-86, March 2015.
[2]. Smita Asthana, Sonia Chauhan, Satyanarayana Labani.. “ Breast and cervical cancer risk in India: An update ”. Indian Journal of Public Health, Volume 58, Issue 1 : 5-1, 2014.
[3]. S Krenn-Pilko, U Langsenlehner, E-M Thurner, T Stojakovic, M Pichler, A Gerger, K S Kapp and T Langsenlehner. “ The elevated preoperative platelet-tolymphocyte ratio predicts poor prognosis in breast cancer patients ”. British Journal of Cancer, Issue 110, pp. 2524–2530, 2014.
[4]. J Kraeima, S Siesling, IM Vliegen, JM Klaase, MJ Ijzerman. “ Individual risk profiling for breast cancer recurrence: towards tailored follow-up schemes ”. British Journal of Cancer, Issue 109, pp. 866–871, 2013.
[5]. S. Eva Singletary, James L. Connolly. “ Breast Cancer Staging: Working With the Sixth Edition of the AJCC Cancer Staging Manual ”. CA Cancer Journal of Clinician, Volume 56, Issue 1, pp. 37–47, 2006.
[6]. FR Balkwill, A Mantovani. “ Cancer-related inflammation: common themes and therapeutic opportunities ”. Seminars in Cancer Biology, Volume 22, Issue 1, pp. 33–40, 2012.
[7]. Yoo Young Lee , Chel Hun Choi, Ha Jeong Kim, Tae Joong Kim, Jeong Won Lee, Je Holee, Duk Soo Bae and Byoung Gie Kim. “ Pretreatment neutrophil: lymphocyte ratio as a prognostic factor in cervical carcinoma ”. AntiCancer Research, Volume 32, Number 4, 2012.
[8]. S Kilin calp, S Coban, H Akinci, M Hamamc, F Karaahmet, Y Coskun . “ Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma ”. European Journal of Cancer Prevention, Volume 2, Number 4 : 328-33, July 2014.
[9]. J Szkandera, A Gerger, B Liegl-Atzwanger, G Absenger, M Stotz, H Samonigg, W Maurer-Ertl, T Stojakovic, F Ploner, A Leithner, M Pichler. “ Validation of the prognostic relevance of plasma C-reactive protein levels in soft-tissue sarcoma patients ”. British Journal of Cancer., Volume 109 : pp. 2316–2322, 2013.
[10]. Navneet Kaur, Amit Attam, Sudipta Saha, S. K. Bhargava. “ Breast Cancer Risk Factor Profile in Indian Women ”. JIMSA., Volume 24, Number 4, 2011.
[11]. Ramchandra Kamath, Kamaleshwar S Mahajan, Lena Ashok, and T S Sanal. “ A Study on Risk Factors of Breast Cancer Among Patients Attending the Tertiary Care Hospital, in Udupi District ”. Indian Journal of Community Medicine, Volume 38, Issue 2, pp. 95–99, 2013.
[12]. Mirco Pistelli, Mariagrazia De Lisa, Zelmira Ballatore, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Matteo Santoni, Elena Maccaroni, Raffaella Bracci, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi and Stefano Cascinu. “ Pre treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients ”. BMC Cancer, Volume 15, Issue 195, pp. 1-9, 2015.
[13]. Jiahuai Wen, Feng Ye, Xiaojia Huang, Shuaijie Li, Lu Yang, Xiangsheng Xiao, and Xiaoming Xie. “ Prognostic Significance of Preoperative Circulating Monocyte Count in Patients With Breast Cancer Based on a Large Cohort Study ”. Medicine., Volume 94, Number 49, pp. 1-7, December 2015.
[14]. Christian Nordqvist. “ Breast Cancer: Causes, Symptoms and Treatments ”. Medical News Today, 2017.
[15]. Musa Mayer. “ Lessons Learned From The Metastatic Breast Cancer Community ”. Seminars in Oncology Nursing, Volume 26, Issue 3, pp. 195-202, 2010.
[16]. Centers for Disease Control and Prevention (CDC) data.
[17]. Indian Council of Medical Research (ICMR) 2016 report.
[18]. National Institute of Cancer Prevention and Research (NICPR) epidemiology data.